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Some possible triggers may include: Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you ought to err along the side of caution and permit the FDA do its job and demand some investigation be done so the public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies will be in business to make money and that they would say anything to keep people on their medications. Researchers discovered that participants using this drug to get a year, dropped a few pounds within a month and have kept the body weight off through the 56 weeks from the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs that are made up of many active ingredient, which might make them more effective and safer. Combo-pilling could be the newest fad or better yet the newest to come under scrutiny and thus it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular will be the fact that as of right now there aren't any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug may also raise blood pressure level and heartbeat, and must not be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high hypertension, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients to the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. An independent report published by Gant Daily in April also stated that naltrexone also utilizes kleptomaniacs and gambling addicts, also. Citing research in the University of Minnesota School of Medicine, Gant Daily reported that this drug conditions kleptomaniacs and chronic gamblers just as with alcohol and opioid addicts'by blocking the consequences of endorphins, that this brain releases when experiencing craving or compulsions.